Yan feng scientific director at bristolmyers squibb. She has held leadership positions in drug development programs spanning discovery biology through to clinical development in the context of both international companies and small. The chinese clinical oncology publishes articles that describe new findings in the field of oncology, provides current and practical information on diagnosis, prevention and clinical investigations of cancer. Volume 31, issue 10 april 1, 20 journal of clinical oncology of.
Rachael hawtin has over 17 years of experience in drug development, encompassing small molecules and biologics for oncology and autoimmune indications. Loxo oncologys very innovative approach complements bayers oncology pipeline with highly differentiated compounds across different treatment modalities, which are being developed to make a meaningful difference for patients suffering from various types of cancer. Proceedings of a workshop advancing progress in the. Use of epoetin and darbepoetin in patients with cancer. The lancet oncology, july 2003, volume 4, issue 7, pages. Applications of nmr will be given that includes screening of fragments, evaluation of lead compounds, and structure determination of molecules and metabolites. Chinese journal of clinical oncology, the influential medical profession. Patients receiving s1based chemotherapy between august 2004 and july 2010 with pathologically proven inoperable gastric cancer and at least 1 measurable lesion were enrolled in this analysis. Jco oncology practice is published by american society of clinical oncology and produced in conjunction with harborside. A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations.
Lentinan prolonged survival in patients with gastric. Abstract background previous trials showed promising antitumor activity and an acceptable safety profile associated with pembrolizumab in patients with early triplenegative breast cancer. Axillary dissection versus no axillary dissection in patients with sentinelnode micrometastases ibcsg 2301. Moss, phd, is the author of 12 books on cancerrelated topics. Jian ye senior director, clinical safety physician. For many patients, by the time cancer is detected, metastasis has already occurred. Alternatively, you can also download the pdf file directly to your computer, from where it can be opened using a pdf reader. Journal of clinical oncology volume 32 number 19 july 2014 free download as pdf file.
Firsttime data with mercks investigational, oral hif2. Lentinan should be widely accepted for the treatment of unresectable or recurrent advanced gastric cancer. To download the pdf, click the download link below. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Top american libraries canadian libraries universal library community texts project gutenberg biodiversity heritage library childrens library. Chinese clinical oncology hepatocellular carcinoma guest editor. In the consumer use study of otc mevacor 6 survey of outcomes among 3,316 consumers in a simulated otc. Nvs plans to put its first novel cancer treatment into phase i testing in 20. Welcome to journal website publication director of the china association for science, chinese anticancer association, tianjin cancer hospital, cancer institute and published in national journals contractors. View jian yes profile on linkedin, the worlds largest professional community. The immunooncology io essentials initiative features a series of health care providerdirected resources to assist in the recognition and management of immunerelated adverse events iraes associated with immune checkpoint inhibitor ici therapy. Professor sun yan, one of the most leading oncologists in china and the general master translator of the nccn guidelines, gave guidance and made deployment on the translation and publication of the nccn guidelines at the meeting.
New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. Clinical oncology vol 16, issue 3, pages 163232 may. Part of the pharmacy and pharmaceutical sciences commons recommended citation. By comparing the three consecutive and welldefined phases in the traditional clinical trial paradigm and the newly adopted paradigm where three phases are. He pointed out that the aim of nccn guidelines is to provide the latest and the best choice in diagnosis and treatment for tumor patients. Clinical oncology vol 1, issue 1, pages 155 september. Pembrolizumab for early triplenegative breast cancer nejm. The former science writer at memorial sloankettering cancer center, for 35 years moss has investigated the validity of many cancer treatments.
Merck works with a broad range of partners, from earlystage science to clinical stage programs, to deliver lifechanging therapies to waiting patients. Other experimental drugs moving through its clinical trials target everything from breast cancer to lung cancer. This is a groundup, discoverybased company with a rich pipeline, said eric. A sixweekly q6w dosing schedule for pembrolizumab based on. Merck to present new data from its broad oncology portfolio and. An ncri initiative to address the infrastructure and capacity deficit in radiotherapy and radiobiology research in the uk. Emphasis will be placed on ensuring that attendees have an understanding of nmr to enable them to become.
Digitoxin is a cardiotonic drug with a narrow therapeutic window. American journal of blood researchan independent peer. Effects and safety of preoperative oral carbohydrate in. A phase i oncology trial aims to determine the maximumtolerated dose mtd of a drugthe highest dose with a toxicity rate close to a prespecified target level, p t. Qian shi department of biostatistics, mayo clinic, rochester, mn, usa, this special section will publish one or two papers. Chemotherapy drug sequencing adam peele, pharmd, bcps, bcop oncology pharmacy manager cone health objectives discuss rationale for chemotherapy sequencing describe adverse events with improper sequencing evaluate common regimens and discuss sequencing background first attempt at systemic treatment of cancer was in 1943. The investigational cancer vaccine tecemotide, when administered with the chemotherapeutic cisplatin, boosted immune response and reduced the number of tumors in mice with lung cancer, a study has. Academic clinical oncology and radiobiology research network acorrn. Larotrectinib is an oral, potent and highly selective trk inhibitor. Tu mm, lee fyf, jones rt, kimball ak, saravia e, graziano rf, coleman b, menard k, yan j. Digitoxin is one of the few cgs that have been extensively studied and have a wellestablished clinical profile 67, 68. Emmett schmidt, lead of external collaborations at merck research.
Lentinan has been used for the treatment of gastric cancer since august 2004 in our hospital in patients who gave informed consent. Final overall survival results of wjtog3405, a randomized phase iii trial comparing gefitinib versus cisplatin with docetaxel as the firstline treatment for patients with stage iiibiv or postoperative recurrent egfr mutationpositive nonsmall cell lung cancer. Digitoxin and its analogs as novel cancer therapeutics. Chinese version of nccn clinical practice guidelines in oncology officially authorized by nccn. Mectizan donation is one for the record books journey for control. Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer.
Launched in march 1963, domestic public offering, is the academic journal founded the first tumor. Chinese journal of clinical oncology editorial department has an excellent working environment, modern office equipment and conditions. Novel approaches to drug development in oncology and immune. American society of clinical oncology and infectious diseases society of america clinical practice guideline update taplitz et al. Pdf oral health status of chinese paediatric and adolescent. The presence of the unstable lactone ring ering is of particular concern, since it undergoes reversible spontaneous. Novel compound inhibits lung cancer growth in lab studies. Novelos therapeutics pivotal phase 3 lung cancer trial does not meet the primary survival endpoint newton, mass.
The lancet oncology, july 2003, volume 4, issue 7, pages 385450. Chinese version of nccn clinical practice guidelines in. Clinical journal of oncology nursing number 2 april 2010 the mission of the clinical journal of oncology nursing, an official publication of ons, is to publish clinically relevant, evidencebased content for oncology nurses in diverse roles and practice settings to use when caring for those affected by cancer. Journal of oncology pharmacy practice conforms to the icmje requirement that clinical trials are registered in a whoapproved public trials registry at or before the time of first patient enrolment as a condition of consideration for publication. Annals of oncology, volume 5, issue 6, july 1994, pages 480481. Cambridge biotech bids to become leading cancer drug maker. Jianda yuan senior medical director, translational. Novartis aims for china trial of novel cancer drug in 20. Journal of oncology pharmacy practice sage publications ltd. This new 3rd edition of the oxford textbook of oncology is a major piece of scholarly work that details the evolution, evidence base and current best practice in multidisciplinary practice in oncology. In the consumer use study of otc mevacor 6 survey of outcomes among 3,316 consumers in a simulated otc setting, individuals with ldl cholesterol between.
Lentinan prolonged survival in patients with gastric cancer. Roy herbst, ensign professor of medicine, chief of medical oncology, and. In japan, a phase iii study comparing therapy with s1lentinan with s1 alone is now underway. Digitoxin has a prolonged halflife and a wellestablished clinical profile. Potential lung cancer vaccine shows renewed promise. A novel organic compound synthesised by a group of scientists from university of madras, iit madras and sri ramachandra university, chennai, has shown it. Outpatient management of fever and neutropenia in adults treated for malignancy. Cardiotoxicity is frequently encountered as the most significant toxicity following digitoxins clinical administration. This course will focus on understanding the type of data that nmr can produce in a small molecule drug discovery environment. More than 80 abstracts involving merck cancer medicines and. Merck has the industrys largest immunooncology clinical research program. However, the clinical use of cpt has been hampered by its low water solubility 26, the presence of a chemically unstable ering 15, low clinical activity, and severe toxicity 16, 17. In 2008 he was recruited to merck as vice president of oncology clinical research. He currently directs the moss reports, a library of reports for patients on over 200 different cancer diagnoses.
Pharmacokinetics and biodistribution of the camptothecin. We will be providing unlimited waivers of publication charges for accepted articles related to covid19. Randomized, phase iii trial of firstline figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin alone in patients with advanced nonsmallcell lung cancer. In china, treatment options for latestage melanoma, particularly for secondline 2l therapy, are limited. Clinical journal of oncology nursing number 1 february 2017 the mission of the clinical journal of oncology nursing, an official publication of ons, is to publish clinically relevant, evidencebased content for oncology nurses in diverse roles and practice settings to use when caring for those affected by cancer. The lancet oncology, april 20, volume 14, issue 4, pages. Bicarbonate treatment for cancer december 2009 townsend. Understanding mumps a leader in immunooncology clinical research meet luis. Weve developed a handy guide of key oncology terms to help those following the latest updates in the field. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. We are committed to sharing findings related to covid19 as quickly and safely as possible. Biological comparison of ovarian cancer resistant cell. Oncology is the largest hospital multispecialty and the contributors to this 3rd edition are all internationally recognised key opinion leaders in their field.
Jianda yuan senior medical director, translational oncology, early oncology development, merck. Volume 31, issue 10 april 1, 20 journal clinical oncology. Cancer is one of the worlds most urgent unmet medical needs. Chemoimmunotherapy combined with lentinan and an s1based regimen might be a candidate for the standard treatment of advanced gastric cancer. Over 80% of patients diagnosed with lung cancer, for example, present with metastatic disease. Volume 5 issue 6 annals of oncology oxford academic. Although details of the new drug candidates were not released, novartis. Clinical oncology in resourcelimited settings article pdf available in infectious agents and cancer 81. Oral health status of chinese paediatric and adolescent oncology patients with chemotherapy in hong kong. Clinical oncology vol 20, issue 5, pages 3286 june 2008. Novel approaches to drug development in oncology and. Christopher gene england 1988 university of louisville follow this and additional works at. Bayer and loxo oncology to develop and commercialize two.1062 911 657 1606 570 1654 548 79 359 252 1457 1124 1399 365 1661 992 1657 27 1552 1035 796 496 1011 5 656 517 1502 625 192 374 1642 1475 10 664 156 1219 331 37 1261 1418 1300 176 1024